Genetic factors and hormones that determine gender. In Stanford at the Tech: Understanding genetics. Since only one of a woman's X chromosomes works in a cell, why aren't more women colorblind?. Biosci41, Stanford University.Ĭhen, Shuai. Mutations, aneuploidy and sex determination. If the two embryos that fuse have different alleles of the coat color gene, the chimeric embryo will have a mixture of cells with different genotypes, and the mature cat will have patchy fur similar to that of a female tortoiseshell.īergmann, D. Instead, some are chimeras, or genetic mosaics, that result from the fusion of two embryos into one during early development. Not all male tortoiseshell kittens have an abnormal number of X chromosomes, however. Male tortoiseshells with an XXY genotype are outwardly male, but are usually sterile (unable to have offspring), with a feline version of the disorder known as Klinefelter syndrome in humans. This results in a patchy tortoiseshell coat pattern like that of a heterozygous female cat. Download: Windows (圆4) - Mac (圆4) - Linux (x8664 AppImage) - Linux (i386 AppImage) - Other. However, only one X can be active in each cell, so one of the two X chromosomes will be randomly inactivated in each of the XXY male's cells during early embryonic development. a fast, feature-rich krunker client written in typescript. In cats (as in humans), male development is specified by the SRY gene on the Y chromosome, so an XXY individual will develop as male. One example of how nondisjunction could lead to an XXY genotype and a tortoiseshell phenotype is shown in the Punnett square below. An XXY genotype can arise through nondisjunction, the failure of sex chromosomes to separate correctly from one another during meiosis.
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